Preview

Proceedings on applied botany, genetics and breeding

Advanced search

Common hop (Humulus lupulus L.): historical and contemporary utilization trends

https://doi.org/10.30901/2227-8834-2025-4-257-268

Abstract

An analytical review is presented to highlight the history and current utilization prospects for one of the most popular and widespread crop plants in many regions of the globe – the common hop (Humulus lupulus L.). It has been used and cultivated for thousands of years. A greater part of its worldwide area of distribution is cultigenic. Common hop was used in brewing and in breadmaking (as a leaven component), served as a nutritional, antimicrobial, sedative or hypnotic agent, and was cultivated for animal feed and medicine, for paper and paint production, and for traditional rituals. The possibilities offered by modern methods in the analysis of the crop’s chemical composition have revived the interest in common hop and significantly expanded its potential for the development of original beer varieties and functional foods, natural hygienic and cosmetic products, and especially pharmaceuticals. The analysis of an extensive bibliography dedicated to studying secondary metabolites in common hop (representing more than 20 classes of organic compounds) showed new prospects of its utilization in anti-inflammatory and hormone substitution therapies, treatment of metabolic syndrome and cancer, and natural insecticide production.

About the Authors

M. M. Silantyeva
Altai State University
Россия

Marina M. Silantyeva, Dr. Sci. (Biology), Chief Researcher

61 Lenina Ave., Barnaul 656049, Russia



O. N. Mironenko
Altai State University
Россия

Olga N. Mironenko, Cand. Sci. (Biology), Leading Researcher

61 Lenina Ave., Barnaul 656049, Russia



Yu. R. Poltaratskaya
Altai State University
Россия

Yulia R. Poltaratskaya, Laboratory Research Assistant

61 Lenina Ave., Barnaul 656049, Russia



References

1. Afanaseva O.G., Ivanov E.A., Makushev A.E. Study of global hops trade and determination of Russia’s role in the product turnover. Special issue “Economy”. Agrarian Bulletin of the Urals. Special Issue “Economy”. 2022;(228):2-17. [in Russian]. DOI: 10.32417/1997-4868-2022-228-13-2-17

2. Afanaseva O.G., Ivanov E.A., Makushev A.E., Danilova N.L. Study of prospects for the development of the aroma and alpha hop world market. Economics of Agriculture of Russia. 2023;(8):129-135. [in Russian]. DOI: 10.32651/238-129

3. Akazawa H., Kohno H., Tokuda N., Suzuki K., Yasukawa Y., Kimura A. et al. Anti-inflammatory and anti-tumor-promoting effects of 5-deprenyllupulonol C and other compounds from Hop (Humulus lupulus L.). Chemistry and Biodiversity. 2012;9(6):1045-1054. DOI: 10.1002/cbdv.201100233

4. ALANICA. Collection of selected articles by A. A. Tuallagov, Doctor of Historical Sciences. Dedicated to his 50th birthday (Sbornik izbrannykh statey doktora istoricheskikh nauk A. A. Tuallagova. K 50-letiyu so dnya rozhdeniya). Vladikavkaz: V.I. Abaev North-Ossetian Institute of Humanitarian and Social Studies; 2017. [in Russian]. URL: https://soigsi.com/books/books2017/tuallagov2017.pdf [дата обращения: 16.08.2025].

5. Allen M.E., Piefer A.J., Cole S.N., Werner J.J., Benziger P.T., Grieneisen L. et al. Characterization of microbial communities populating the inflorescences of Humulus lupulus L. Journal of the American Society of Brewing Chemists. 2019;77(4):243-250. DOI: 10.1080/03610470.2019.1667739

6. Almaguer C., Schönberger C., Gastl M., Arendt E.K., Becker T. Humulus lupulus – a story that begs to be told. A review. Journal of the Institute of Brewing. 2014;120(4):289-314. DOI: 10.1002/jib.160

7. Alonso-Esteban J.I., Pinela J., Barros L., Ćirić A., Soković M., Calhelha R.C. et al. Phenolic composition and antioxidant, antimicrobial and cytotoxic properties of hop (Humulus lupulus L.) seeds. Industrial Crops and Products. 2019;134:154-159. DOI: 10.1016/j.indcrop.2019.04.001

8. Annenkov N. (comp.). Botanical dictionary: a reference book for botanists, farmers, gardeners, foresters, pharmacists, doctors, potion-makers, and travelers in Russia, and rural residents in general (Botanicheskiy slovar: spravochnaya kniga dlya botanikov, selskikh khozyaev, sadovodov, lesovodov, farmatsevtov, vrachey, drogistov, puteshestvennikov po Rossii i voobshche selskikh zhiteley). St. Petersburg: Imperial Academy of Sciences; 1878. [in Russian]

9. Astray G., Gullón P., Gullón B., Munekata P.E.S., Lorenzo J.M. Humulus lupulus L. as a natural source of functional biomolecules. Applied Sciences. 2020;10(15):5074. DOI: 10.3390/app10155074

10. Aydin T., Bayrak N., Baran E., Cakir A. Insecticidal effects of extracts of Humulus lupulus (hops) L. cones and its principal component, xanthohumol. Bulletin of Entomological Research. 2017;107(4):543-549. DOI: 10.1017/S0007485317000256

11. Aydin T., Senturk M., Kazaz C., Cakir A. Inhibitory effects and kinetic-docking studies of xanthohumol from Humulus lupulus cones against carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase. Natural Product Communications. 2019;14(10):1-6. DOI: 10.1177/1934578X19881503

12. Ban Z., Qin H., Mitchell A.J., Liu B., Zhang F., Weng J.K., et al. Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(33):E5223-E5232. DOI: 10.1073/pnas.1802223115

13. Bedini S., Flamini G., Cosci F., Ascrizzi R., Benelli G., Conti B. Cannabis sativa and Humulus lupulus essential oils as novel control tools against the invasive mosquito Aedes albopictus and freshwater snail Physella acuta. Industrial Crops and Products. 2016;85:318-323. DOI: 10.1016/j.indcrop.2016.03.008

14. Bedini S., Flamini G., Girardi J., Cosci F., Conti B. Not just for beer: Evaluation of spent hops (Humulus lupulus L.) as a source of eco-friendly repellents for insect pests of stored foods. Journal of Pest Science. 2015;88(3):583-592. DOI: 10.1007/s10340-015-0647-1

15. Belenovskaya L.M., Medvedeva L.I. Cannabaceae Endl. – The hemp family (Konoplevye). Genus Humulus L. – Hop (Khmel). H. lupulus L. – Common hop (Khmel obyknovenny) In: A.L. Budantsev (ed.). Plant Resources of Russia: Wild Flowering Plants, Their Component Composition and Biological Activity (Dikorastushchiye tsvetkovye rasteniya, ikh komponentny sostav i biologicheskaya aktivnost). Vol. 1. Families Magnoliaсeae, Juglandaceae, Ulmaceae, Moraceae, Cannabaceae, and Urticaceae. St. Petersburg; Moscow: KMK; 2008. [in Russian]

16. Bhattacharya S., Virani S., Zavro M., Haas G.J. Inhibition of Streptococcus mutans and other oral streptococci by hop (Humulus lupulus L.) constituents. Economic Botany. 2002;57:118-125. DOI: 10.1663/0013-0001(2003)057[0118:IOSMAO]2.0.CO;2

17. Bogdanova K., Röderova M., Kolar M., Langova K., Dusek M., Jost P. et al. Antibiofilm activity of bioactive hop compounds humulone, lupulone and xanthohumol toward susceptible and resistant staphylococci. Research in Microbiology. 2018;169(3):127-134. DOI: 10.1016/j.resmic.2017.12.005

18. Bolton J.L., Dunlap T.L., Hajirahkimkhan A., Mbachu O., Chen S.N., Chadwick L. et al. The multiple biological targets of hops and bioactive compounds. Chemical Research in Toxicology. 2019;32(2):222-233. DOI: 10.1021/ACS.CHEMRESTOX.8B00345

19. Bortoluzzi C., Menten J.F., Romano G.G., Pereira R., Napty G.S. Effect of hops β-acids (Humulus lupulus) on performance and intestinal health of broiler chickens. The Journal of Applied Poultry Research. 2014;23(3):437-443. DOI: 10.3382/japr.2013-00926

20. Bouback T.A., Aljohani A.M., Albeshri A., Al-Talhi H., Moatasim Y., GabAllah M. et al. Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study. Biotechnology and Biotechnological Equipment. 2023;37(1):167-179. DOI: 10.1080/13102818.2022.2158133

21. Brendel S., Hofmann T., Granvogl M. Characterization of key aroma compounds in pellets of different hop varieties (Humulus lupulus L.) by means of the sensomics approach. Journal of Agricultural and Food Chemistry. 2019;67(43):12044-12053. DOI: 10.1021/acs.jafc.9b05174

22. British Hop Association: [website]. Available from: https://www.britishhops.org.uk/contact [accessed Aug. 21, 2025].

23. Carbone K., Gervasi F. An updated review of the genus Humulus: a valuable source of bioactive compounds for health and disease prevention. Plants. 2022;11(24):3434. DOI: 10.3390/ plants11243434

24. Carter P.R., Oelke E.A., Kaminski A.R., Hanson C.V., Combs S.M., Doll J.D. et al. Hop. In: Alternative Field Crops Manual. Madison, WI: University of Wisconsin; 1990. [online]. Available from: https://corn.aae.wisc.edu/Crops/Hop.aspx [accessed Aug. 06, 2025].

25. Čermák P., Palečková V., Houška M., Strohalm J., Novotná P., Mikyška A. et al. Inhibitory effects of fresh hops on Helicobacter pylori strains. Czech Journal of Food Sciences. 2015;33(4):302-307. DOI: 10.17221/261/2014-CJFS

26. Cornell M. Hist-brewing: hops – was ‘Ageing mead’? Shadow Island Games [website]; 2001. Available from: http://www.pbm.com/pipermail/hist-brewing/2001/003188.html [accessed Aug. 21, 2025].

27. Dal V.I. Explanatory dictionary of the living Great Russian language. Vol. 4. Moscow: Terra; 1995. [in Russian]

28. Daraei Garmakhany A., Mirzaei H., Shalarami Kh. Investigation of the effect of flower and leaf ethanolic extract of Humulus lupulus plant on the shelf life and quality attributes of strawberry fruits. Journal of Food Science and Technology (Iran). 2021;17(109):75-90. [in Persian] DOI: 10.29252/fsct.17.12.08

29. De Candolle A. Géographie botanique raisonnée; ou, Exposition des faits principales et des lois concernant la distribution géographique des plantes de l’époque actuelle. Paris: V. Masson; 1855. [in French] DOI: 10.5962/bhl.title.62718

30. DeNoma J.S. Hop genetic resources. Corvallis, OR: USDA ARS National Clonal Germplasm Repository [website]; 2000. Available from: http://www.arsgrin.gov/ars/PacWest/Corvallis/ncgr/humulus/huminfo.html [accessed Aug. 08, 2025].

31. Di Lodovico S., Menghini L., Ferrante C., Recchia E., Castro-Amorim J., Gameiro P. et al. Hop extract: an efficacious antimicrobial and anti-biofilm agent against multidrug-resistant staphylococci strains and Cutibacterium acnes. Frontiers in Microbiology. 2020;11:1852. DOI: 10.3389/fmicb.2020.01852

32. Duke J.A. Humulus lupulus L. In: J.A. Duke. Handbook of Energy Crops. West Lafayette, IN: Purdue University; 1983. [online]. Available from: http://www.hort.purdue.edu/newcrop/duke_energy/Humulus_lupulus.html [accessed Aug. 11, 2025].

33. Dyakova Т.А. Phraseological representation of some wedding rites (based on the Ukrainian dialects of Vostochnaya Slobozhanscshina). Review of Omsk State Pedagogical University. Humanitarian Research. 2015;3(7):41-44. [in Russian]

34. Edwardson J.R. Hops – Their botany, history, production and utilization. Economic Botany. 1952;6:160-175. DOI: 10.1007/BF02984875

35. Erkkola R., Vervarcke S., Vansteelandt S., Rompotti P., De Keukeleire D., Heyerick A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine. 2010;17(6):389-396. DOI: 10.1016/j.phymed.2010.01.007

36. Eyres G.T., Marriott P.J., Dufour J.P. Comparison of odor-active compounds in the spicy fraction of hop (Humulus lupulus L.) essential oil from four different varieties. Journal of Agricultural and Food Chemistry. 2007;55(15):6252-6261. DOI: 10.1021/jf070739t

37. Gerhäuser C. Beer constituents as potential cancer chemopreventive agents. European Journal of Cancer. 2005;41(13):1941-1954. DOI: 10.1016/j.ejca.2005.04.012

38. Hamm A.K., Manter D.K., Kirkwood J.S., Wolfe L.M., Cox-York K., Weir T.L. The effect of hops (Humulus lupulus L.) extract supplementation on weight gain, adiposity and intestinal function in ovariectomized mice. Nutrients. 2019;11(12):3004. DOI: 10.3390/nu11123004

39. Hilton J.F. Hops – Into the Millennium. Hopsteiner [website]; 2001. Available from: http://hopsteiner.com/history5.html [accessed Aug. 12, 2025].

40. Hornsey I.S. A history of beer and brewing. Cambridge: The Royal Society of Chemistry; 2003.

41. Howard G.A. The constituents and brewing behaviour of hops. In: A.H. Burgess, N. Polunin (eds). Hops: Botany, Cultivation, and Utilization. London: Leonard Hill; 1964. p.36-52.

42. Hristyuk A.V., Kas’yanov G.I. Hop in brewing. Beer and Beverages. 2007;(1):10-12. [in Russian]

43. Iniguez A.B., Zhu M.J. Hop bioactive compounds in prevention of nutrition related noncommunicable diseases. Critical Reviews in Food Science and Nutrition. 2021;61(11):1900-1913. DOI: 10.1080/10408398.2020.1767537

44. International Plant Names Index (IPNI): [website]. Available from: http://www.ipni.org [accessed Aug. 21, 2025].

45. Kanukyants K.A. Chemistry of malt and beer (Khimiya soloda i piva). Moscow: Agropromizdat; 1990. [in Russian]

46. Kolyada E.V., Tolchikova A.I. Concerning the issue of the chemical composition of hops (K voprosu o khimicheskom sostave khmelya). Current Problems of the Humanities and Natural Sciences. 2017;(4-3):49-51. [in Russian]

47. Korpelainen H., Pietiläinen M. Hop (Humulus lupulus L.): traditional and present use, and future potential. Economic Botany. 2021;75(4):302-322. DOI: 10.1007/s12231-021-09528-1

48. Kovalev N.I. Russian cooking (Russkaya kulinariya). Leningrad: IMA-Press; 1990. [in Russian]

49. Krottenthaler M. Hops. In: H.M. Eßlinger (ed.). Handbook of Brewing: Processes, Technology, Markets. Weinheim: Wiley‐VCH Verlag GmbH & Co. KGaA; 2009. p.85-104. DOI: 10.1002/9783527623488.ch3

50. Lamy V., Roussi S., Chaabi M., Gossé F., Schall N., Lobstein A. et al. Chemopreventive effects of lupulone, a hop β-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis. 2007;28(7):1575-1581. DOI: 10.1093/carcin/bgm080

51. Latypova G.M., Ayupova G.V., Bubenchikova V.N., Galimova D.F., Batyrova E.D., Shafikova S.F. Study for identification of bitter acids in Humulus lupulus. Challenges in Modern Medicine. 2012;10-2(129):65-69. [in Russian]

52. Lee J.C., Kundu J.K., Hwang D.M., Na H.K., Surh Y.J. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis. 2007;28(7):1491-1498. DOI: 10.1093/carcin/bgm054

53. Lempereur M., Majewska C., Brunquers A., Wongpramud S., Valet B., Janssens P. et al. Tetrahydro-iso-alpha acids antagonize estrogen receptor alpha activity in MCF-7 breast cancer cells. International Journal of Endocrinology. 2016;2016:9747863. DOI: 10.1155/2016/9747863

54. Lobanov P.P. (ed.). Agricultural encyclopedia (Selskokhozyaystvennaya entsiklopediya). Vol. 5. T – Ya. Moscow: Selkhozgiz; 1956. [in Russian]

55. Mahli A., Koch A., Fresse K., Schiergens T., Thasler W.E., Schönberger C. et al. Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation, and fibrosis. Laboratory Investigations. 2018;98(12):1614-1626. DOI: 10.1038/s41374-018-0112-x

56. Milosta G.M., Lapa V.V. Agrobiological principles of hop cultivation in the Republic of Belarus: a monograph (Agrobiologicheskiye osnovy vyrashchivaniya khmelya v Respublike Belarus: monografiya). Grodno: Grodno State Agrarian University; 2010. [in Russian]

57. Milosta G.M., Zhebrak I.S., Pirahouskaya H.V. Dependence of hops cones anti-microbe activity on the fertilizer system. Soil Science and Agrochemistry. 2009;1(42):227-234. [in Russian]

58. Minaeva V.G. Medicinal plants of Siberia (Lekarstvennye rasteniya Sibiri). Novosibirsk: Nauka; 1970. [in Russian]

59. Miranda C.L., Elias V.D., Hay J.J., Choi J., Reed R.L., Stevens J.F. Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Archives of Biochemistry and Biophysics. 2016;599:22-30. DOI: 10.1016/j.abb.2016.03.008

60. Mottin V.H., Nemitz M.C., Medeiros-Neves B., Rossi R.C., Zuanazzi J.A., von Poser G.L. et al. Dermatological uses of Humulus lupulus – A review of scientific and technological progress. Revista Brasileira de Farmacognosia. 2025;35(5):849-860. DOI: 10.1007/s43450-025-00673-5

61. Muzykiewicz A., Nowak A., Zielonka–Brzezicka J., Florkowska K., Duchnik W., Klimowicz A. Comparison of antioxidant activity of extracts of hop leaves harvested in different years. Herba Polonica. 2019;65(3):1-9. DOI: 10.2478/hepo-2019-0013

62. Naraine S.G.U., Small E. Germplasm sources of protective glandular leaf trichomes of hop (Humulus lupulus). Genetic Resources and Crop Evolution. 2017;64(3):1491-1497. DOI: 10.1007/s10722-017-0540-2

63. Neve R.A. Hops. In: N.W. Simmonds (ed.). Evolution of Crop Plants. London; New York, NY: Longman Inc.; 1976. p.339.

64. Oshugi M., Basnet P., Kadota S., Ishii E., Tamura T., Okumura Y. et al. Antibacterial activity of traditional medicines and an active constituent lupulone from Humulus lupulus against Helicobacter pylori. Journal of Traditional Medicines. 1997;14:186-191.

65. Pavlovskaya G.P., Ruzhnikov Yu.N. Beer alcoholism: its debut and outcome (Pivnoy alkogolizm: debyut i iskhod). Izvestia Ural Federal University. Series 1: Issues in Education, Science and Culture. 2004;(32):157-160. [in Russian]

66. Perry L.P. Growing hops in New England – COH 27. University of Vermont Extension System. Department of Plant and Soil Science [website]; 1994. Available from: http://www.uvm.edu/~pass/perry/hopsne.html [accessed Aug. 16, 2025].

67. Philips N., Samuel P., Lozano T., Gvaladze A., Guzman B., Siomyk H. et al. Effects of Humulus lupulus extract or its components on viability, lipid peroxidation, and expression of vascular endothelial growth factor in melanoma cells and fibroblasts. Madridge Journal of Clinical Research. 2017;1(1):15-19. DOI: 10.18689/mjcr-1000103

68. Pokhlebkin V.V. Entertaining cooking (Zanimatelnaya kulinariya). Moscow: Light and Food Industry; 1983. [in Russian]

69. Quer P.F. Plantas medicinales. El dioscórides renovado. Barcelona: Editorial Labor; 1995. [in Spanish]

70. Santarelli V., Neri L., Carbone K., Macchioni V., Faieta M., Pittia P. Conventional and innovative extraction technologies to produce food-grade hop extracts: Influence on bitter acids content and volatile organic compounds profile. Journal Food Science. 2023;88(4):1308-1324. DOI: 10.1111/1750-3841.16487

71. Shipilov A.V. Russian everyday culture: food, clothing, housing (from ancient times to the 18th century): a monograph (Russkaya bytovaya kultura: pishcha, odezhda, zhilishche [s drevneyshikh vremen do XVIII veka]: monografiya). Voronezh: Voronezh State Pedagogical University; 2007. [in Russian]

72. Silantyeva M.M., Mironenko O.N., Ovcharova N.V., Chukhina I.G., Poltaratskaya Yu.R., Nebylitsa A.V. et al. Phytocenotic arrangement of the common hop in the south of Western Siberia. Proceedings on Applied Botany, Genetics and Breeding. 2024;185(4):20-31. [in Russian]. DOI: 10.30901/2227-8834-2024-4-20-31

73. Srinivasan V., Goldberg D., Haas G.J. Contributions to the antimicrobial spectrum of hop constituents. Economic Botany. 2005;58(sp1):230-238. DOI: 10.1663/0013-0001(2004)58[S230:CTTASO]2.0.CO;2

74. Standard operating procedure to preserve and maintain the genetic collection of common hop (Humulus lupulus L.) in the field to identify genetic sources of valuable agronomic traits (Standartnaya operatsionnaya protsedura po sokhraneniyu i podderzhaniyu geneticheskoy kollektsii khmelya obyknovennogo (Humulus lupulus L.) v polevykh usloviyakh po vydeleniyu geneticheskikh istochnikov khozyajstvenno tsennykh priznakov). Opytny Settlement: Chuvash Research Institute of Agriculture; 2019. [in Russian]. URL: http://ниисх.рф/images/СОП.pdf [дата обращения: 15.08.2025].

75. State Register of Varieties and Hybrids of Agricultural Plants Admitted for Usage (National List): official publication. Moscow; Rosinformagrotekh; 2024. [in Russian]

76. Tataurova L.V. The life support system of a Siberian village in the 17th–18th centuries based on archaeological materials: adaptation and development (Sistema zhizneobespecheniya Sibirskoy derevni XVII–XVIII vv. po arkheologicheskim materialam: adaptatsiya i razvitiye). In: Integrating Archaeological and Ethnographic Research: Conference Proceedings. Vol. 1. Irkutsk: Irkutsk State Technical University; 2013. p.254-258. [in Russian]. URL: https://heritage-institute.ru/wp-content/uploads/2017/05/IntegraciyaZarheologicheskih_i_ehtnograficheskih_issledovanij_Tom_1.pdf [дата обращения: 16.08.2025].

77. Telyatyev V.V. Useful plants of Central Siberia (Poleznye rasteniya Tsentralnoy Sibiri). Irkutsk: East Siberian Book Publishers; 1985. [in Russian]

78. Tembrock L.R., McAleer J.M., Gilligan T.M. A revision of native North American Humulus (Cannabaceae). Journal of the Botanical Research Institute of Texas. 2016;10(1):11-30.

79. Tkachenko K., Varfolomeeva E. Essential oils of the different species of the Lamiaceae family as a means of combating phytophagous and plant diseases. In: A. Beskopylny, M. Shamtsyan, V. Artiukh (eds). Lecture Notes in Networks and Systems. Vol. 575. XV International Scientific Conference “INTERAGROMASH 2022”. Cham: Springer; 2023. p.1831-1838. Available from: https://link.springer.com/chapter/10.1007/978-3-031-21219-2_203 [accessed Aug. 12, 2025].

80. Tkachenko K., Varfolomeeva E. Prospects for the use of essential oils as repellants and/or insecticides. Tropical Journal of Natural Product Research. 2022;6(6):831-835. DOI:10.26538/tjnpr/v6i6.1

81. Tkachenko K.G., Varfolomeeva E.A., Hikal W.M., Mahmoud A.A., Smaoui S., Kačániová M. et al. Experience with combinations of fatty oil and essential oil mixtures against Trialeurodes vaporariorum Westw. in the Peter the Great Botanical Garden. International Journal of Advanced Multidisciplinary Research and Studies. 2023;3(6):527-535.

82. Tronina T., Popłoński J., Bartmańska A. Flavonoids as phytoestrogenic components of hops and beer. Molecules. 2020;25(18):4201. DOI: 10.3390/molecules25184201

83. Tseselsky T. Mead-making, or the art of producing drinks from honey and fruits (Medovareniye, ili iskusstvo proizvodstva napitkov iz myoda i fruktov). Yekaterinoslav: Y.A. Krasnopoler’s Printing House; 1910. [in Russian]

84. Van Cleemput M., Cattoor K., De Bosscher K., Haegeman G., De Keukeleire D., Heyerick A. Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. Review. Journal of Natural Products. 2009;72(6):1220-1230. DOI: 10.1021/np800740m

85. Van Opstaele F., De Causmaecker B., Aerts G., De Cooman L. Characterization of novel varietal floral hop aromas by headspace solid phase microextraction and gas chroma tography-mass spectrometry/olfactometry. Journal of Agricultural and Food Chemistry. 2012;60(50):12270-12281. DOI: 10.1021/jf304421d

86. Vereshchagin V.I., Sobolevskaya K.A., Yakubova A.I. Useful plants of Western Siberia (Poleznye rasteniya Zapadnoy Sibiri). Moscow; Leningrad: USSR Academy of Sciences; 1959. [in Russian]

87. Wang G., Dixon R.A. Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(24):9914-9919. DOI: 10.1073/pnas.0904069106

88. Weber N., Biehler K., Schwabe K., Haarhaus B., Quirin K.W., Frank U. et al. Hop extract acts as an anti-oxidant with antimicrobial effects against Propionibacterium acnes and Staphylococcus aureus. Molecules. 2019;24(2):223. DOI: 10.3390/molecules24020223

89. Wendakoon C., Gagnon D., Koenig M., Dwarakanath S. Hops (Humulus lupulus) strobile extract and its major components show strong antibacterial activity against methicillin-resistant Staphylococcus aureus. Journal of Medicinally Active Plants. 2018;7(1-4):12-18. DOI: 10.7275/1af3-eg20

90. WFO Plant List. Snapshots of the taxonomy. Genus Lupulus L.: [website]. Available from: https://about.worldfloraonline.org/taxon/wfo-4000018428-2024-12 [accessed Mar. 16, 2025].

91. Wilson D.G. Plant remains from the Graveney boat and the early history of Humulus lupulus L. in W. Europe. New Phytologist. 1975;75(3):627-648. DOI: 10.1111/j.1469-8137.1975.tb01429.x

92. Xin G., Wei Z., Ji C., Zheng H., Gu J., Ma L. Et al. Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release. Free Radical Biology and Medicine. 2017;108:247-257. DOI: 10.1016/j.freeradbiomed.2017.02.018

93. Yan Y.F., Wu T.L., Du S.S., Wu Z.R., Hu Y.M., Zhang Z.J. et al. The antifungal mechanism of isoxanthohumol from Humulus lupulus L. International Journal of Molecular Sciences. 2021;22(19):10853. DOI: 10.3390/ijms221910853

94. Yasukawa K., Takeuchi M., Takido M. Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology. 1995;52(2):156-158. DOI: 10.1159/000227448

95. Zanoli P., Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L. Journal of Ethnopharmacology. 2008;116(3):383-396. DOI: 10.1016/j.jep.2008.01.011


Review

For citations:


Silantyeva M.M., Mironenko O.N., Poltaratskaya Yu.R. Common hop (Humulus lupulus L.): historical and contemporary utilization trends. Proceedings on applied botany, genetics and breeding. 2025;186(4):257-268. (In Russ.) https://doi.org/10.30901/2227-8834-2025-4-257-268

Views: 184

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2227-8834 (Print)
ISSN 2619-0982 (Online)